I have been trying to do this for a while and I hit on a winning combination.
You have to have art in office and 2 anything in airport hanger to fill bag.
Solo Cayo Perico Heist on Hard
I come in on sub to drainage grate then west up stairs, kill 2, then solo guy at top of stairs in between 2 cabins when he comes to south wall, run to near front gate kill 1 then run to stairs and kill 1 up there, run back to panther cage and kill 1 on stairs up to office, 1 in front of office. get safe and art then hack lift, get main target then back up in lift, I can I get to main gate easily by turn right jump wall, left up stair and avoid guard without shooting then exit.
Kill guy with motor bike and ride it off the cliffs near where wall ends, scuba all the the way to airport kill 1 at hanger get stashes and run and scuba to submarine off coast.
I beat the time by 25 seconds!