- Play until you unlock Random starting weapons rune & Unlock Flayer of Memories weapon
- Restart run until you start with Flayer
- Heavy charge attack everything in Sunken with Flayer (Use the platforms to your advantage)
- Leave one enemy left to kill you.
- Respawn with around 1-3 hundred Knowledge. (If you use the rune to spawn more enemies, your amount will be on the higher end.)
- Spend it all (even if you cant unlock the next thing)
- Restart run
- Spawn with the same amount you just had before spending
- Repeat and Profit.
Found this out by accident, used it to unlock everything for achievements.