Loot River – Easy Knowledge Farm (Buy Everything Fast)

The Method

Note: Credit goes to XplicitJer

• Play until you unlock Random starting weapons rune & Unlock Flayer of Memories weapon
• Restart run until you start with Flayer
• Heavy charge attack everything in Sunken with Flayer (Use the platforms to your advantage)
• Leave one enemy left to kill you.
• Respawn with around 1-3 hundred Knowledge. (If you use the rune to spawn more enemies, your amount will be on the higher end.)
• Spend it all (even if you cant unlock the next thing)
• Restart run
• Spawn with the same amount you just had before spending
• Repeat and Profit.

Found this out by accident, used it to unlock everything for achievements.