Smog and Marrow Tips
Beat him with poison team. Her was “poison every enemy by 1”, and i’ve also got smackback and aimless fury charms.
Helper was musroom guy with triple poison attack, and kernel shielder. Also poison transfer on death clunker.
I’ve spent early turns by shielding hero, then landed good amount of poison on both of major annoyances, and then posion transfer helped to do the job. Shields and some form of AOE is crucial here.