Point and click can be a challenge on this game when trying to kill some bosses. Here are some videos on how to do it.
Boss #1 – Flayed Mrs. Driscoll
Boss #2 – Flayed Billy
Save everything for the last part.
Boss #3 – Mind Flayer Monster
When camera focus on the boss be at stores segment.
Boss #4 – Final Boss: Grigori
Build Joyce trinket.